果冻传媒

Dr. Paolo D鈥橝vino has been studying the protein-protein interactions during animal cytokinesis using Drosophila and mammalian cultured cells as models. The most recent work is now at bioRxiv https://www.biorxiv.org/content/10.1101/569459v1 "The midbody interactome reveals new unexpected roles for PP1 phosphatases in cytokinesis鈥�. He is staying from Monday to Friday this week. If you wish to talk to him, please contact Masanori (M.Mishima@warwick.ac.uk).

https://www.path.cam.ac.uk/directory/paolo-davino

The abstract: E-cadherin cell-cell adhesion is vital for maintaining the integrity of epithelial tissues. For the lifetime of a tissue, E-cadherin molecules on the cell surface connect cells to their neighbours by physically binding E-cadherin molecules on these neighbouring cells. However, despite appearing static, E-cadherin cell-cell adhesion is highly dynamic and undergoes constant remodelling. The key process in remodelling E-cadherin cell-cell adhesion is recycling, whereby the protein is internalized from the cell surface within membrane vesicles and is then transported along an intricate route of intracellular compartments. Following a sorting decision, it can be recycled back to the cell surface or degraded. The correct progression of each step of this process determines the total amount of E-cadherin present at the cell surface and thus, adhesion strength. Using Drosophila as a model system our lab is investigating the molecular mechanisms and regulation of E-cadherin trafficking and its role during the development of an organism.